Secondary sclerosing cholangitis in critically ill patients with febrile infection-related epilepsy syndrome (FIRES): a case series
The high incidence of SC-CIP in our cohort of patients with FIRES suggests a link between these two rare conditions, likely related to prolonged intensive care, hyperinflammation and polytherapy, including ketamine use. Vigilant monitoring of liver disease progression in critically ill patients with FIRES and similar predisposing factors may allow early recognition of SC-CIP and improved patient outcomes.
Authors
- Lorenzo Muccioli (ORCID: https://orcid.org/0000-0001-6827-0099)
- Lorenzo Ferri (ORCID: https://orcid.org/0000-0003-0148-9795)
- Elena Pasini (ORCID: https://orcid.org/0000-0002-1069-892X)
- Francesca Bisulli (ORCID: https://orcid.org/0000-0002-1109-7296)
- Alessandro Granito (ORCID: https://orcid.org/0000-0002-0637-739X)
- Paolo Tinuper (ORCID: https://orcid.org/0000-0002-0588-3063)
- Rocco Liguori (ORCID: https://orcid.org/0000-0002-1815-1013)
- Carlo Alberto Castioni (ORCID: https://orcid.org/0000-0002-8895-425X)
- Lidia Di Vito (ORCID: https://orcid.org/0000-0002-0266-6776)
- Laura Licchetta (ORCID: https://orcid.org/0000-0001-7979-9895)
- Manuel Moneti (ORCID: https://orcid.org/0009-0003-0773-9924)
- Giovanni Vitale (ORCID: https://orcid.org/0000-0002-5416-7645)
Institutions
- Azienda USL di Bologna (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3389/fneur.2025.1557377
- Citations
- 2
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 2.64
Funders
- Ministero della Salute