Multi-omics analysis reveals CMTR1 upregulation in cancer and roles in ribosomal protein gene expression and tumor growth
Our findings establish CMTR1 as an important player in cancer biology, regulating critical aspects of RNA metabolism and ribosome biogenesis. The study highlights CMTR1's potential as a therapeutic target in certain cancer types and provides a foundation for developing novel cancer treatments targeting mRNA cap methylation.
Authors
- Zeng‐Quan Yang (ORCID: https://orcid.org/0000-0002-3658-0081)
- Ion John Campeanu
- Lisa Polin (ORCID: https://orcid.org/0000-0002-9189-055X)
- Yuanyuan Jiang (ORCID: https://orcid.org/0000-0002-7438-4081)
- Sijana H. Dzinic (ORCID: https://orcid.org/0000-0002-8065-2687)
- Hilda Afisllari
Institutions
- Wayne State University (US)
- The Barbara Ann Karmanos Cancer Institute (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s12964-025-02147-6
- Citations
- 7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- U.S. Department of Defense
- Elsa U. Pardee Foundation
- Barbara Ann Karmanos Cancer Institute
- DMC Foundation
- National Institutes of Health