UCMSCs-derived exosomal SLIT2 alleviates ischemic stroke through the β-catenin/TCF4/USP20 signaling pathway
UCMSCs-derived exosomal SLIT2 activated TCF4 by promoting β-catenin nuclear translocation, which transcriptionally upregulated USP20 expression, thereby attenuating OGD/R-induced neuroncell damage and ultimately leading to inhibition of IS progression.
Authors
- Ying Xia (ORCID: https://orcid.org/0000-0001-6706-0911)
- Rongjun Xiao
- Mei Chen (ORCID: https://orcid.org/0000-0001-6809-147X)
- Qingsong Wang
- Jun Peng (ORCID: https://orcid.org/0000-0003-2590-0024)
- Xiqi Hu (ORCID: https://orcid.org/0009-0008-6636-0769)
Institutions
- Central South University (CN)
Publication Details
- Journal
- International Journal of Neuroscience
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1080/00207454.2025.2497936
- Citations
- 1
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94