Adult Patients with HbS-Only Phenotype of Sickle Cell Disease Have a Decreased Arginine/Asymmetric Dimethylarginine Ratio
The HbS-only patients with leg ulcers have lower arginine, higher ADMA, and lower arginine/ADMA ratio when compared to those without leg ulcers and HbAA controls. The prospective arginine/ADMA ratio should be studied to screen patients with higher risks of leg ulcers that could be prevented with specifically targeted care. .
Authors
- Angela Ogechukwu Ugwu
- Anazoeze Jude Madu (ORCID: https://orcid.org/0000-0003-4284-2428)
- Ikechukwu Okwudili Anigbogu
- Chiemelie Raluchukwu Onwasigwe
- Chidiebele Michael Egolum
Institutions
- University of Nigeria Teaching Hospital (NG)
Publication Details
- Journal
- Medical Principles and Practice
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1159/000546047
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00