Multimodality Approach to a Pediatric Craniopharyngioma with Mixed Histological Features

We report a unique case of pediatric craniopharyngioma with mixed histological features that were managed successfully via a multimodality approach. Emphases are on molecular profiling of the said lesion, minimizing permanent morbidity and maintenance of quality of life for a growing child. In the context of tumors with BRAFV600E mutations, the use of targeted monotherapy can be considered.

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Publication Details

Journal
Pediatric Neurosurgery
Published
2025-04-23
DOI
https://doi.org/10.1159/000546046
Primary Topic
Pituitary Gland Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Multimodality Approach to a Pediatric Craniopharyngioma with Mixed Histological Features

Sharmila Devi, Sharon Y. Y. Low, Ngee Lek, Khurshid Merchant et al.
Pediatric Neurosurgery
Pituitary Gland Disorders and Treatments
article

Multimodality Approach to a Pediatric Craniopharyngioma with Mixed Histological Features

Sharmila Devi, Sharon Y. Y. Low, Ngee Lek, Khurshid Merchant, Marielle V. Fortier, Sze Jet Aw, Lee Ping Ng, Enrica E. K. Tan
article en

Abstract

We report a unique case of pediatric craniopharyngioma with mixed histological features that were managed successfully via a multimodality approach. Emphases are on molecular profiling of the said lesion, minimizing permanent morbidity and maintenance of quality of life for a growing child. In the context of tumors with BRAFV600E mutations, the use of targeted monotherapy can be considered.

Pediatric NeurosurgeryVol. 60(3)
SingHealth Duke-NUS Academic Medical Centre (SG), KK Women's and Children's Hospital (SG), National Neuroscience Institute (SG)
Good health and well-being
Openalex Percentile: Top 89%
Pituitary Gland Disorders and Treatments
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