CircRNA profiling reveals circSMC1B that promotes bovine male germline stem cells proliferation and apoptosis via sponging let-7i
Our research elucidates that circSMC1B, through let-7i binding, promotes bovine mGSCs proliferation and apoptosis by targeting HMGA1/NR6A1. These findings provide valuable resources for studying the functional aspects of circRNAs in testis development and enhance our understanding of the biological function of circSMC1B in promoting bull spermatogenesis.
Authors
- Ruihua Dang (ORCID: https://orcid.org/0000-0002-4818-5871)
- Halima Jafari
- Zhaofei Wang (ORCID: https://orcid.org/0000-0003-0235-7030)
- Chuzhao Lei (ORCID: https://orcid.org/0000-0003-1647-1037)
- Yuan Gao (ORCID: https://orcid.org/0000-0002-9510-6515)
- Cong Li (ORCID: https://orcid.org/0000-0003-2588-4781)
- Ge Yang (ORCID: https://orcid.org/0000-0002-5915-2266)
Institutions
- North West Agriculture and Forestry University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s12864-025-11556-3
- Citations
- 2
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Northwest A and F University