Formononetin ameliorates depression-like behaviors through rebalancing microglia M1/M2 polarization and inhibiting NLRP3 inflammasome: involvement of activating PPARα-mediated autophagy
Our study firstly demonstrated that FMN can rebalance microglia M1/M2 polarization and inhibit NLRP3 inflammasome, with the involvement of activating PPARα-mediated autophagy to ameliorate depression-like behaviors, which provides a novel view to elucidate antidepressant mechanisms of FMN and also offers a potential therapeutic target for depression.
Authors
- Lei Tian (ORCID: https://orcid.org/0000-0002-9395-7762)
- Yucheng Li (ORCID: https://orcid.org/0000-0003-4611-8314)
- Yuan Liu (ORCID: https://orcid.org/0000-0002-1415-4460)
- Liming Liu (ORCID: https://orcid.org/0000-0003-0005-5880)
- Zibo Li (ORCID: https://orcid.org/0000-0002-1063-0298)
- Pan Su (ORCID: https://orcid.org/0000-0002-7133-1777)
- Erping Xu
- Ming Bai (ORCID: https://orcid.org/0009-0003-5317-440X)
- Shuaijun Peng
Institutions
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1186/s10020-025-01217-2
- Citations
- 11
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.36
Funders
- Henan University of Chinese Medicine
- National Natural Science Foundation of China
- Henan University
- Henan Provincial Science and Technology Research Project