Expression of the stem cell markers NANOG and SOX2 in the cervical squamous carcinogenesis
Contrary to p16, NANOG and SOX2 could be effective for distinguishing LSIL from non-dysplastic changes. NANOG and SOX2 could be surrogate markers for differentiating LSIL from HSIL. Moreover, SOX2 could be helpful for distinguishing HSIL/CIN 2 from HSIL/CIN 3. Further studies with larger numbers of patients and molecular insights are needed.
Authors
- Margareta Žlajpah (ORCID: https://orcid.org/0000-0002-0937-3845)
- Margareta Strojan Fležar (ORCID: https://orcid.org/0000-0001-6390-2253)
- Kristina Fujs Komloš
- Mario Poljak (ORCID: https://orcid.org/0000-0002-3216-7564)
- Miklós Koren (ORCID: https://orcid.org/0000-0003-4495-7560)
Institutions
- University of Ljubljana (SI)
Publication Details
- Journal
- Radiology and Oncology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.2478/raon-2025-0026
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00