Dual Activation of Organoboron for the Ion-Pair-Mediated Synthesis of Hindered Alkyl Fluorides
A novel electrochemical approach for the synthesis of hindered alkyl fluorides has been developed. The protocol grants access to a diverse array of tertiary and secondary alkyl fluorides using readily attainable organoboron precursors under mild conditions. The efficiency of the system stems from the dual activation of the redox-active borate intermediate, providing both electrophilic and nucleophilic reaction partners in the form of an internally generated ion pair.
Authors
- Tae Yeong Im
- Won Seok Ham (ORCID: https://orcid.org/0000-0002-6239-5795)
- Su Yong Go (ORCID: https://orcid.org/0000-0003-0949-9824)
- J. E. Lee (ORCID: https://orcid.org/0009-0001-3732-0804)
- Hong Geun Lee (ORCID: https://orcid.org/0000-0002-9982-4733)
- Soo Young Kim (ORCID: https://orcid.org/0000-0002-8919-3456)
Institutions
- Seoul National University (KR)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1021/acs.orglett.5c01127
- Citations
- 2
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.58
Funders
- Seoul National University
- National Research Foundation of Korea