Deciphering a proliferation-essential gene signature based on CRISPR-Cas9 screening to predict prognosis and characterize the immune microenvironment in HNSCC
This study identifies a novel PEGs signature that effectively predicts HNSCC prognosis and stratifies patients by survival risk. PSMC1 was identified as a key gene promoting malignant progression, offering potential as a therapeutic target for HNSCC.
Authors
- Junyan He (ORCID: https://orcid.org/0000-0002-8334-3484)
- Xiuzhong Yao (ORCID: https://orcid.org/0000-0002-4856-0985)
- Kai Pang
- Pian Li
- Wentao Xiao
- Xing Ren
Institutions
- Tumor Hospital of Guangxi Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s12885-025-14181-1
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province