Impact of Acute Antioxidant and Tetrahydrobiopterin (BH <sub>4</sub> ) Administration on Locomotor Muscle Microvascular Function in Patients With Heart Failure
Together, these results provide new evidence for the efficacy of acute BH<sub>4</sub> administration to improve some aspects of locomotor muscle microvascular function in patients with HFrEF and HFpEF, with no apparent benefit of AOx administration, alone or in combination with BH<sub>4</sub>, in either group. These findings lend further conceptual support for the nitric oxide pathway as a modifiable target in the treatment of heart failure.
Authors
- Josephine B. Wright
- D. Walter Wray (ORCID: https://orcid.org/0000-0002-6907-1734)
- Markus Amann (ORCID: https://orcid.org/0000-0002-4012-8880)
- Jayson R. Gifford (ORCID: https://orcid.org/0000-0002-6034-306X)
- Stephen M. Ratchford (ORCID: https://orcid.org/0000-0002-6300-7600)
- Kanokwan Bunsawat (ORCID: https://orcid.org/0000-0002-5950-6634)
- Heather L. Clifton (ORCID: https://orcid.org/0000-0003-4546-4346)
- Jeremy K. Alpenglow
- D. Taylor La Salle (ORCID: https://orcid.org/0000-0001-7956-8704)
- John Ryan (ORCID: https://orcid.org/0000-0002-9203-5512)
- Taylor S. Thurston (ORCID: https://orcid.org/0000-0002-4536-3054)
Institutions
- Brigham Young University (US)
- University of Utah (US)
- George E. Wahlen Department of VA Medical Center (US)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1161/circheartfailure.124.012446
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00