Intracerebral Hemorrhage in Patients With CADASIL: Additive Impact of the <i>NOTCH3</i> R544C Variant and Hypertension?
Both the <i>NOTCH3</i> R544C variant and hypertension appear to be independent risk factors for ICH in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, with a potential additive effect. However, due to the study's cross-sectional design and population-specific factors, causality cannot be established. Prospective studies are thus needed to validate these findings and clarify underlying mechanisms.
Authors
- Sung‐Chun Tang (ORCID: https://orcid.org/0000-0003-3731-5973)
- Ruiting Zhang (ORCID: https://orcid.org/0000-0002-8293-4979)
- Dominique Hervé (ORCID: https://orcid.org/0000-0001-6197-6275)
- Stéphanie Guey (ORCID: https://orcid.org/0000-0001-6096-3595)
- Chih‐Hao Chen (ORCID: https://orcid.org/0000-0002-1258-8775)
- Yu‐Wen Cheng (ORCID: https://orcid.org/0000-0002-3054-6333)
- Hugues Chabriat (ORCID: https://orcid.org/0000-0001-8436-6074)
- Sophie Tézenas du Montcel (ORCID: https://orcid.org/0000-0002-2866-4330)
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Lariboisière (FR)
- National Taiwan University Hospital (TW)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Stroke
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1161/strokeaha.124.050484
- Citations
- 2
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.78