Right Ventricular Stiffening and Function Are Associated With Main Pulmonary Artery Remodeling in a Rat Model of Pulmonary Hypertension
Compositional, structural, and mechanical changes in mPA correlate with adverse RV remodeling, mechanics, function, and coupling in PA hypertension. Therefore, increasing mechanical compliance of the large PAs may be an important and novel therapeutic strategy for mitigating RV failure.
Authors
- Kana Yazaki (ORCID: https://orcid.org/0000-0003-3546-481X)
- J. Paul Santerre (ORCID: https://orcid.org/0000-0003-3373-6463)
- John D. Dauz (ORCID: https://orcid.org/0000-0001-9879-0896)
- Bahram Mirani (ORCID: https://orcid.org/0000-0002-4770-684X)
- Michelle P. Bendeck (ORCID: https://orcid.org/0000-0002-9140-8508)
- Neda Latifi (ORCID: https://orcid.org/0000-0002-8099-8354)
- Craig A. Simmons (ORCID: https://orcid.org/0000-0001-7729-1772)
- Mark K. Friedberg (ORCID: https://orcid.org/0000-0002-4108-5560)
Institutions
- Beth Israel Deaconess Medical Center (US)
- University of Toronto (CA)
- University of South Florida (US)
- Hospital for Sick Children (CA)
- Ted Rogers Centre for Heart Research (CA)
- SickKids Foundation (CA)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1161/atvbaha.124.321354
- Citations
- 2
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.04