Metabolic reprogramming in glioblastoma: a rare case of recurrence to scalp metastasis
Beyond established risk factors such as craniotomy, biopsies, ventricular shunting, and radiation therapy, our findings suggest that metabolic reprogramming plays a crucial role in the transition from recurrent to metastatic GB. Targeting these metabolic shifts could provide new avenues for managing and preventing extracranial metastasis in GB, making this an important focus for future research.
Authors
- Mahsa Bourbour (ORCID: https://orcid.org/0000-0001-5951-5090)
- Sedigheh Alamdar
- Amir Barzegar Behrooz (ORCID: https://orcid.org/0000-0002-8113-5809)
- Somayeh Piroozmand
- Jabar Lotfi
- Mahmoud Aghaei (ORCID: https://orcid.org/0000-0002-1775-8761)
- Fatemeh Jusheghani
- Shahla Shojaei (ORCID: https://orcid.org/0000-0003-3611-0730)
- Ahmad Pour‐Rashidi (ORCID: https://orcid.org/0000-0002-4544-5527)
- Saeid Ghavami (ORCID: https://orcid.org/0000-0001-5948-508X)
- Narges Zolfaghari
- Elham Nazar (ORCID: https://orcid.org/0000-0001-6182-3893)
- Ahmad Nasimian (ORCID: https://orcid.org/0000-0002-6415-2105)
- Negar Azarpira
- Fatemeh Mollasalehi
- Hamid Latifi-Navid
Institutions
- Northwestern University (US)
- Isfahan University of Medical Sciences (IR)
- Tarbiat Modares University (IR)
- Shiraz University (IR)
- Milad Hospital (IR)
- CancerCare Manitoba (CA)
- Biotechnology Research Center (IR)
- Children's Hospital Research Institute of Manitoba (CA)
- Sina Hospital (IR)
- National Institute of Genetic Engineering and Biotechnology (IR)
- Institute for Research in Fundamental Sciences (IR)
- Research Institute in Oncology and Hematology (CA)
- University of Manitoba (CA)
- Alzahra University (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- BJC Reports
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1038/s44276-025-00134-5
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94