Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities
Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A (1) and B (2), and a new phthalide monomer (3), were obtained from the rhizomes of Angelica sinensis. Their structures were established through spectroscopic methods, quantum calculations, and chiral HPLC analysis. Compounds 1 and 2 were [2 + 2] and [4 + 2] cycloadducts of phthalide monomers, and their hypothetical biogenetic origin was proposed. Compounds 2, (+)-2, (-)-2, 4, (+)-4, and (-)-4 exhibited significant inhibitory activity against NO production with IC<sub>50</sub> values range from 1.23 to 5.55 μM.
Authors
- Hongyan Wen (ORCID: https://orcid.org/0000-0002-0007-5411)
- Yu Zhang
- Sheng Li (ORCID: https://orcid.org/0009-0007-1820-3446)
Institutions
- Kunming Institute of Botany (CN)
- Yunnan University (CN)
- Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Natural Products and Bioprospecting
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1007/s13659-025-00512-z
- Citations
- 4
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 9.53
Funders
- National Key Research and Development Program of China