Dual aVß8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Tumor Immunity
Targeting TGFβ signaling using an anti-αVβ8 blocker can impact anti-tumor immunity through different possible mechanisms, of which we highlight the rescuing of B-cell function through synergy with PD-1 checkpoint blockade therapy. Our work underscores the critical role of intratumoral B-cell immunity in enhancing immunotherapy against brain tumors.
Authors
- Dean Sheppard (ORCID: https://orcid.org/0000-0002-6277-2036)
- David Hou (ORCID: https://orcid.org/0000-0002-1224-0146)
- Gustavo Vazquez-Cervantes
- Ronit Patel (ORCID: https://orcid.org/0009-0000-8905-7684)
- Mark Dapash (ORCID: https://orcid.org/0000-0002-8695-2373)
- Víctor A. Arrieta (ORCID: https://orcid.org/0000-0003-2738-9741)
- Joshua L. Katz (ORCID: https://orcid.org/0000-0003-4133-5731)
- Alina R Murphy (ORCID: https://orcid.org/0000-0003-1862-050X)
- Brandyn Castro (ORCID: https://orcid.org/0000-0003-3412-9761)
- Leah K. Billingham
- Catalina Lee-Chang (ORCID: https://orcid.org/0000-0002-7675-2124)
- Tzu-Yi Chia
- Crismita Dmello (ORCID: https://orcid.org/0000-0002-1688-9663)
- Hanxiao Wan
- Maciej S. Lesniak (ORCID: https://orcid.org/0000-0002-0096-5107)
- Adam M. Sonabend (ORCID: https://orcid.org/0000-0002-8347-1945)
- Rebecca Du (ORCID: https://orcid.org/0000-0003-0865-874X)
- Dieter Henrik Heiland (ORCID: https://orcid.org/0000-0002-9258-3033)
- Jason Miska (ORCID: https://orcid.org/0000-0001-9608-2810)
- Aurora Lopez‐Rosas (ORCID: https://orcid.org/0000-0001-6712-5738)
- Yu Han (ORCID: https://orcid.org/0000-0003-0552-720X)
- Peng Zhang (ORCID: https://orcid.org/0000-0001-9856-7571)
- Si Wang (ORCID: https://orcid.org/0000-0003-2431-0612)
Institutions
- Northwestern University (US)
- Allen Institute for Brain Science (US)
- University of Illinois Urbana-Champaign (US)
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- University of California, San Francisco (US)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Medical Center Freiburg (DE)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Neurological Surgery (US)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- University of San Francisco (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1093/neuonc/noaf106
- Citations
- 6
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 9.73