Comparative Analysis of Lysophosphatidic Acid Levels in Fibromyalgia and Other Painful Conditions in Female Patients
This study provides novel insights into the role of LPA in FM and other chronic pain conditions. Although ATX levels were unchanged in FM, a positive correlation between serum ATX and LPA supports the role of ATX in LPA conversion. These findings suggest complex lipid dysregulation in FM, with LPA potentially modulating pain pathways. Further research is needed to clarify LPA's role and its potential as a biomarker or therapeutic target.
Authors
- Nils Simon (ORCID: https://orcid.org/0000-0002-6559-1863)
- Joana Menezes (ORCID: https://orcid.org/0009-0009-0215-3565)
- Lars Tanum (ORCID: https://orcid.org/0000-0003-4001-6325)
- Matthew A. Hunt (ORCID: https://orcid.org/0000-0001-6800-8592)
- Jenny E. Jakobsson (ORCID: https://orcid.org/0000-0003-0470-5940)
- Alex Bersellini Farinotti (ORCID: https://orcid.org/0000-0002-3607-1332)
- Camilla I. Svensson (ORCID: https://orcid.org/0000-0001-7980-4631)
- Emerson Krock (ORCID: https://orcid.org/0000-0002-8501-2945)
- Kim Kultima (ORCID: https://orcid.org/0000-0002-0680-1410)
- Sigita Venckute Larsson (ORCID: https://orcid.org/0009-0005-6187-0231)
- Eva Kosek
Institutions
- Uppsala University (SE)
- Akershus University Hospital (NO)
- McGill University Health Centre (CA)
- Karolinska Institutet (SE)
Publication Details
- Journal
- European Journal of Pain
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1002/ejp.70022
- Citations
- 1
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Eli Lilly and Company
- European Commission
- Karolinska Institutet
- Knut och Alice Wallenbergs Stiftelse
- Stockholms Läns Landsting
- Vetenskapsrådet
- Uppsala Universitet
- Svenska Läkaresällskapet
- Reumatikerförbundet
- Foundation for Research in Rheumatology
- Region Uppsala