The impact of different rates of sodium reduction on the central nervous system in acute hypernatremia in rabbits
For acute hypernatremia that develops within 48 h, sodium reduction rates exceeding 1 mEq/L/h are associated with greater increases in ICP and more severe brain edema. Therefore, for managing acute hypernatremia,our result prompted that sodium reduction rates might not exceed 1 mEq/L/h.
Authors
- Ling Ma (ORCID: https://orcid.org/0000-0002-1485-8994)
- Rui Cao (ORCID: https://orcid.org/0000-0001-7757-7615)
- Rongli Yang (ORCID: https://orcid.org/0000-0002-5212-1088)
- Hongyu Wu (ORCID: https://orcid.org/0000-0003-1278-4183)
- Shuo Wu (ORCID: https://orcid.org/0000-0003-3684-4363)
- Rui Feng (ORCID: https://orcid.org/0000-0002-8408-6512)
- Xue Geng (ORCID: https://orcid.org/0000-0001-9601-2476)
Institutions
- Dalian Municipal Central Hospital (CN)
Publication Details
- Journal
- Critical Care
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s13054-025-05377-9
- Primary Topic
- Electrolyte and hormonal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00