E2F8-induced GRPEL2 promoted colorectal cancer progression via targeting TIGAR
Our work illustrated the oncogenic role of GRPEL2 in CRC development and determined the molecular mechanism of E2F8/GRPEL2/TIGAR pathway. These findings will provide novel insights and promising therapeutic targets for CRC treatment in the future.
Authors
- Jing Deng (ORCID: https://orcid.org/0000-0003-3157-5723)
- Li Wang
- Min Mao (ORCID: https://orcid.org/0000-0002-0139-1723)
- Wei Tang (ORCID: https://orcid.org/0009-0004-5346-8368)
- Cheng Song (ORCID: https://orcid.org/0000-0003-2221-7772)
- Siyuan Peng (ORCID: https://orcid.org/0000-0003-4365-8243)
- Lei Zhao (ORCID: https://orcid.org/0000-0002-6824-6459)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Hunan Cancer Hospital (CN)
- Hunan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12967-025-06451-0
- Citations
- 1
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.23
Funders
- Natural Science Foundation of Hunan Province