Immunogenic Properties of a Novel Hepatitis A Vaccine Candidate Based on a Fast-Growing Viral Strain
Our findings indicated that the fast-growing HM175-HP strain has similar immunogenic properties to the vaccine prototype-like HM175-L0, making it a promising candidate to reduce the elevated costs and time-consuming procedures of producing the current HAV vaccines. The novel HM175-HP-based vaccine would therefore facilitate mass vaccination programs and prevent vaccine shortages.
Authors
- María J. Rodríguez-Lagunas (ORCID: https://orcid.org/0000-0001-7870-8250)
- Àngels Franch (ORCID: https://orcid.org/0000-0002-2362-1374)
- Margarida Castell (ORCID: https://orcid.org/0000-0001-5408-0593)
- Rosa M Pintó (ORCID: https://orcid.org/0000-0003-1382-6648)
- Gemma Chavarria-Miró (ORCID: https://orcid.org/0000-0003-3933-8693)
- Susana Guix (ORCID: https://orcid.org/0000-0002-1588-3198)
- Malén Massot‐Cladera (ORCID: https://orcid.org/0000-0002-5220-2793)
- Albert Bosch (ORCID: https://orcid.org/0000-0002-8111-9059)
- María Isabel Costafreda (ORCID: https://orcid.org/0000-0002-3114-3034)
- Alba Arrebola (ORCID: https://orcid.org/0000-0003-1369-9108)
- Albert Blanco
- Adán Martínez-Velázquez (ORCID: https://orcid.org/0000-0003-1848-2143)
Institutions
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Vaccines
- Published
- 2025-04-23
- DOI
- https://doi.org/10.3390/vaccines13050446
- Primary Topic
- Hepatitis Viruses Studies and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundació Bosch i Gimpera
- Agència de Gestió d'Ajuts Universitaris i de Recerca