Application value of baicalein in the management of periprosthetic joint infection: a preliminary in vitro study
Baicalein shows significant bactericidal effects and effectively inhibits S. aureus biofilm formation. These findings suggest its potential as a promising local antibacterial agent for postoperative continuous intra-articular lavage in the treatment of S. aureus-related early postoperative or acute hematogenous PJIs.
Authors
- Xing Yang (ORCID: https://orcid.org/0000-0002-0860-6037)
- Weishen Chen (ORCID: https://orcid.org/0000-0003-3469-842X)
- Puyi Sheng (ORCID: https://orcid.org/0000-0002-5898-2161)
- Dongwei Huang (ORCID: https://orcid.org/0000-0003-1124-2753)
- Chenghan Chu (ORCID: https://orcid.org/0009-0009-4552-520X)
- Baiqi Pan (ORCID: https://orcid.org/0000-0002-3127-240X)
- Aerman Alimu
- Lingli Long (ORCID: https://orcid.org/0000-0002-4022-2076)
- Xiaoyu Wu (ORCID: https://orcid.org/0009-0002-5426-5373)
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12906-025-04888-w
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- China Postdoctoral Science Foundation