Guidance for conducting and evaluating serological surveys to assess interruption of yaws transmission in the context of an eradication target
This document provides a summary of guidance developed for national programmes on conducting serosurveys to assess yaws transmission status, with the objective of confirming yaws seroprevalence below 1% at each of three serosurveys over a period of 3-10 years after reporting the last case of active yaws in a region. It proposes active testing of children aged 1-5 years through population-based surveys and includes recommendations on survey design, sample size determination, sampling of primary sampling units (PSUs) within an evaluation unit, sampling of households within PSUs, integration with existing public health surveys, and follow-up protocols for positive results. Geospatial analysis and sustained surveillance are recommended for accurate assessment of whether transmission interruption has been achieved.
Authors
- Louise Dyson (ORCID: https://orcid.org/0000-0001-9788-4858)
- Sung Hye Kim (ORCID: https://orcid.org/0000-0003-3608-0324)
- John O. Gyapong (ORCID: https://orcid.org/0000-0002-8415-1468)
- Mahoutondji Yves Thierry Barogui
- Patrick Agana-Nsiire (ORCID: https://orcid.org/0000-0002-4736-9652)
- Julie Jacobson (ORCID: https://orcid.org/0000-0002-8243-6427)
- Ghislain Emmanuel Sopoh (ORCID: https://orcid.org/0000-0003-1237-1047)
- C R Revankar
- Kingsley Asiedu (ORCID: https://orcid.org/0000-0001-5383-3047)
- Michael Marks (ORCID: https://orcid.org/0000-0002-7585-4743)
- Katherine Gass (ORCID: https://orcid.org/0000-0002-2084-8039)
- Peter J. Diggle (ORCID: https://orcid.org/0000-0003-3521-5020)
- Susana Vaz Nery (ORCID: https://orcid.org/0000-0002-2399-7785)
- Lance Allyn Waller (ORCID: https://orcid.org/0000-0001-5002-8886)
- Philip J. Cooper (ORCID: https://orcid.org/0000-0002-6770-6871)
- Anthony W. Solomon (ORCID: https://orcid.org/0000-0001-7101-6649)
- Daniel Argaw Dagne
- John Kaldor (ORCID: https://orcid.org/0000-0002-7639-4355)
- Gillian Stresman (ORCID: https://orcid.org/0000-0002-6897-5459)
- Zaw Lin (ORCID: https://orcid.org/0009-0008-3596-5837)
- Aya Yajima (ORCID: https://orcid.org/0000-0002-9631-7074)
- Belen L. Dofitas (ORCID: https://orcid.org/0000-0001-5494-9455)
- Kazim Hizbullah Sanikullah
- Priya Pathak (ORCID: https://orcid.org/0000-0002-1157-5550)
- Chris Drakeley (ORCID: https://orcid.org/0000-0003-4863-075X)
- Ronaldo Carvalho Scholte
Institutions
- Emory University (US)
- St George's, University of London (GB)
- Liverpool School of Tropical Medicine (GB)
- University of Health and Allied Sciences (GH)
- University of South Florida (US)
- Grameen Foundation (US)
- Brunswick (United States) (US)
- UNSW Sydney (AU)
- University of Warwick (GB)
- World Health Organization Regional Office for the Americas (US)
- London School of Hygiene & Tropical Medicine (GB)
- World Health Organization (CH)
- World Health Organization Regional Office for South-East Asia (IN)
- Université d'Abomey-Calavi (BJ)
- The Task Force for Global Health (US)
- World Health Organization Regional Office for Africa (CG)
- Universidad Internacional del Ecuador (EC)
- World Health Organization Regional Office for the Western Pacific (PH)
- Fundació Lluita contra les Infeccions (ES)
- Hanyang University (KR)
- University of the Philippines Manila (PH)
- Lancaster University (GB)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1371/journal.pntd.0012899
- Citations
- 2
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.33