Analysis of Serum microRNAs During the Development of Experimental Autoimmune Uveoretinitis in Rats

Hierarchical cluster analysis and PCA showed distinctly different miRNA profiles at baseline versus after IRBP immunization. Upregulation of serum miRNA-146a-5p and miRNA-150-5p was observed in the effector and resolution phases of EAU. Analysis of circulating miRNAs may help to delineate systemic epigenetic changes occurring in the development of EAU, and may lead to new insights in our understanding of human uveitis.

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Publication Details

Journal
Ocular Immunology and Inflammation
Published
2025-04-23
DOI
https://doi.org/10.1080/09273948.2025.2483430
Primary Topic
Ocular Diseases and Behçet’s Syndrome
Type
article
Field-Weighted Citation Impact
0.00
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article

Analysis of Serum microRNAs During the Development of Experimental Autoimmune Uveoretinitis in Rats

Shoko Saito, Takayo Watanabe, Hiroshi Keino, Ichiro Takasaki et al.
Ocular Immunology and Inflammation
Ocular Diseases and Behçet’s Syndrome
article

Analysis of Serum microRNAs During the Development of Experimental Autoimmune Uveoretinitis in Rats

Shoko Saito, Takayo Watanabe, Hiroshi Keino, Ichiro Takasaki, Annabelle A. Okada
article en

Abstract

Hierarchical cluster analysis and PCA showed distinctly different miRNA profiles at baseline versus after IRBP immunization. Upregulation of serum miRNA-146a-5p and miRNA-150-5p was observed in the effector and resolution phases of EAU. Analysis of circulating miRNAs may help to delineate systemic epigenetic changes occurring in the development of EAU, and may lead to new insights in our understanding of human uveitis.

Ocular Immunology and InflammationVol. 33(6)
Kyorin University (JP), University of Toyama (JP)
Zero hunger
Openalex Percentile: Top 86%
Ocular Diseases and Behçet’s Syndrome
DOISourceOpenAlex
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Analysis of Serum microRNAs During the Development of Experimental Autoimmune Uveoretinitis in Rats — Shoko Saito, Takayo Watanabe, et al. · Ocular Immunology and Inflammation (2025) | TGRS Research Map | TGRS