Macrophage-Hosted <i>Porphyromonas gingivalis</i> Is a Risk Factor for Cataract Development
Chronic infection with PG can access the lens epithelium via macrophages during stress conditions, which promotes cataract development by possibly elevating oxidative stress, apoptosis, and epithelial-mesenchymal transition in lens tissues. PG infection is a novel a risk factor for cataract development.
Authors
- Xiumei Kong
- Fengling Yuan
- Ke Qiu (ORCID: https://orcid.org/0000-0001-9493-0345)
- Yanzhong Hu (ORCID: https://orcid.org/0000-0002-8269-4629)
- Hongmei Mu
- Hongwei Tian
- Mingya Cao (ORCID: https://orcid.org/0009-0008-9911-3991)
- Weikai Guo (ORCID: https://orcid.org/0000-0001-9361-3903)
- Xiukun Cui (ORCID: https://orcid.org/0000-0003-2555-3413)
- Shuxin Huang (ORCID: https://orcid.org/0000-0002-0634-4870)
- Cuncun Ke
- Fengyan Zhang (ORCID: https://orcid.org/0000-0002-4138-689X)
- Jing Li (ORCID: https://orcid.org/0000-0001-9392-6600)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-9224-6299)
- Mingli Wang (ORCID: https://orcid.org/0000-0003-3002-3855)
- Hui Li (ORCID: https://orcid.org/0000-0001-5592-6052)
- Dongzhe Zhang (ORCID: https://orcid.org/0009-0002-2908-4570)
- Keke Zhu (ORCID: https://orcid.org/0009-0007-6129-0039)
- Mengyun Liu (ORCID: https://orcid.org/0000-0002-7796-1884)
- Jin Luo
- Iqbal Khan
- Tong Xie
- Junwei Qu
Institutions
- Hubei University of Medicine (CN)
- Henan University (CN)
- China National Pharmaceutical Group Corporation (China) (CN)
- Dongfeng General Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1167/iovs.66.4.68
- Citations
- 2
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 2.93