Peripheral-central immune crosstalk in Parkinson’s disease and its association with clinical severity
This exploratory study suggests that peripheral and central immune changes are closely linked in PD, and relevant to clinical disease severity. These findings warrant further validation and exploration to identify immune biomarkers linked to disease state, as well as candidate therapeutic targets.
Authors
- Caroline H. Williams‐Gray (ORCID: https://orcid.org/0000-0002-2648-9743)
- Tim D. Fryer (ORCID: https://orcid.org/0000-0003-1555-9790)
- Julia C. Greenland (ORCID: https://orcid.org/0000-0001-9267-0586)
- Marta Camacho (ORCID: https://orcid.org/0000-0002-1490-5703)
- Jonathan Holbrook (ORCID: https://orcid.org/0000-0001-8660-0282)
- Lakmini Kahanawita
- Young T. Hong
Institutions
- University of Cambridge (GB)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.bbi.2025.04.028
- Citations
- 4
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- Cure Parkinson's Trust
- NIHR Cambridge Biomedical Research Centre
- Cambridge Centre for Parkinson-Plus