Streamlined strategy for discovering active compounds for nephrolithiasis treatment from herbal medicines using the fruit fly model
We developed an efficient strategy for identifying core components of TCMs for kidney stones treatment using a fruit fly model combined with chemical isolation and identification techniques. This approach led to the discovery of three novel potential compounds for controlling kidney stones. Validated in mammalian models, these findings underscore the fruit fly model's utility in uncovering bioactive substances from TCMs, laying the groundwork for future research and the development of novel kidney stones therapies.
Authors
- Xinghua Jin (ORCID: https://orcid.org/0000-0002-8883-5234)
- Yu Wei (ORCID: https://orcid.org/0000-0001-8473-6856)
- Zhimou Guo (ORCID: https://orcid.org/0000-0001-7129-186X)
- Dekun Wang (ORCID: https://orcid.org/0000-0002-1779-8376)
- Youxin Li (ORCID: https://orcid.org/0000-0002-0812-744X)
- Yaodong Miao (ORCID: https://orcid.org/0000-0002-6627-5694)
- Tianxiang Li (ORCID: https://orcid.org/0000-0002-0432-0699)
- Donghai Xia
- Zhiguang Yuchi (ORCID: https://orcid.org/0000-0003-2595-9106)
- Shiyu Du (ORCID: https://orcid.org/0000-0001-6707-3915)
- Yingjie Ju
- Shixiang Sun (ORCID: https://orcid.org/0000-0001-5499-2963)
- Lingfei Wang (ORCID: https://orcid.org/0000-0003-4550-4838)
- Xiaoyue Tan (ORCID: https://orcid.org/0000-0002-3306-3919)
- Weiwei Tang (ORCID: https://orcid.org/0000-0002-8516-819X)
- Yunuo Ren
- Wen Jie Zhang (ORCID: https://orcid.org/0009-0007-6671-0637)
- Yiwen Wang (ORCID: https://orcid.org/0009-0000-3220-943X)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Tianjin University of Science and Technology (CN)
- Tianjin University (CN)
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Nankai University (CN)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
- Tianjin Hospital (CN)
- State Key Laboratory of Chemical Engineering (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.jep.2025.119846
- Primary Topic
- Heavy Metals in Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tianjin Municipal Education Commission