Detection Bias in EHR-Based Research on Clinical Exposures and Dementia
In this cohort study of 2 large datasets, diagnoses of several conditions associated with varying risks of dementia were associated with a higher short-term likelihood of dementia diagnosis. This finding suggests that diagnostic bias or misdiagnoses may lead to spurious associations between conditions requiring clinical care and subsequent dementia diagnoses.
Authors
- M. Maria Glymour (ORCID: https://orcid.org/0000-0001-9644-3081)
- Deborah Blacker (ORCID: https://orcid.org/0000-0001-6107-7376)
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Peter Buto
- John Kornak (ORCID: https://orcid.org/0000-0002-0089-0619)
- Eva Raphael (ORCID: https://orcid.org/0000-0003-2854-0247)
- Scott C. Zimmerman (ORCID: https://orcid.org/0000-0002-4431-6520)
- Catherine Schaefer (ORCID: https://orcid.org/0000-0003-2644-055X)
- Minhyuk Choi (ORCID: https://orcid.org/0009-0000-6658-5054)
- Jingxuan Wang (ORCID: https://orcid.org/0000-0002-9387-0480)
- Ruijia Chen (ORCID: https://orcid.org/0000-0002-2759-9290)
- John Daniel Kelly (ORCID: https://orcid.org/0000-0002-7616-0321)
Institutions
- Boston University (US)
- Kaiser Permanente (US)
- Harvard University (US)
- University of California, San Francisco (US)
- San Francisco Foundation (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.6637
- Citations
- 4
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 4.90
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Abbott Laboratories
- Gilead Sciences
- National Institutes of Health
- National Institute on Aging
- National Institute of Allergy and Infectious Diseases