6-Gingerol, an active compound of ginger, attenuates NASH-HCC progression by reprogramming tumor-associated macrophage via the NOX2/Src/MAPK signaling pathway
This study proves that 6-gingerol, the primary active compound in ginger, plays a role in attenuating the progression of NASH-HCC by inhibiting the proliferation and migration of tumor cells, or reprogramming TAMs to the M1 phenotype via the NOX2/Src/MAPK signaling pathway and activating the TAM-mediated immune responses.
Authors
- Wei Xiang (ORCID: https://orcid.org/0000-0001-5394-9189)
- Qiurui Li (ORCID: https://orcid.org/0009-0002-3677-0093)
- Meng Wang (ORCID: https://orcid.org/0000-0002-3457-5908)
- Mingming Zhang (ORCID: https://orcid.org/0000-0001-6907-4049)
- Jianwei Wang (ORCID: https://orcid.org/0000-0002-2832-4205)
- Pan Li (ORCID: https://orcid.org/0000-0001-6522-2446)
- Chunli Li (ORCID: https://orcid.org/0000-0001-7095-5820)
- Ling Yao (ORCID: https://orcid.org/0009-0005-5898-6807)
- Xuekuan Huang (ORCID: https://orcid.org/0000-0002-9507-6678)
- Shang Wang
- Chengdan Deng
Institutions
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12906-025-04890-2
- Citations
- 2
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing