Catalase: A New Potential Allergen in Hypersensitivity to Avocado

Avocado (Persea americana), a tropical fruit from the Lauraceae family, has gained significant attention in recent decades owing to its health benefits [1,2].While allergic reactions to avocado are well-documented, they are generally mild and associated with latex-fruit syndrome, which is driven primarily by chitinase (Pers a 1).However, hypersensitivity reactions outside this syndrome have also been reported, implicating additional proteins as potential allergens.These include profilin, polygalacturonase, glucanase, thaumatin-like protein, and isoflavone reductase-like protein [1].We report the case of a 44-year-old Colombian woman with a history of severe seasonal allergic rhinitis (AR) triggered by grass-pollen.Thirty minutes after consuming a piece of fully ripe Hass avocado, she experienced pruritus, generalized hives, facial erythema, dyspnea, and 2 episodes of diarrhea requiring emergency medical attention.Of note, she had engaged in strenuous house cleaning 20 minutes before the reaction.She also reported oral and hand itching when consuming or handling oranges, tomatoes, mangoes, and papaya, although she tolerated other fruits and denied any symptoms related to latex exposure.The patient gave her informed consent for the publication of this case report.The results of skin prick testing (SPT) with aeroallergens (Dermatophagoides pteronyssinus, Lepidoglyphus destructor, Alternaria alternata, Aspergillus fumigatus, dog and cat dander,