Combined Spatial and Dosimetric Recurrence Pattern Analysis in Head and Neck Squamous Cell Carcinoma Following Postoperative (Chemo)radiotherapy
The predominance of high-dose recurrences suggests that biological tumor resistance is a key driver of treatment failure, highlighting the necessity to refine postoperative risk stratification and integrate tumor biology into dose escalation decisions. The low incidence of isolated nodal recurrences in electively treated neck regions supports the feasibility of volumetric de-escalation of postoperative radiotherapy. This approach might not only be feasible for HPV-associated oropharyngeal cancers but also for HPV-negative tumors, provided that accurate nodal staging has been conducted.
Authors
- Maximilian Deng (ORCID: https://orcid.org/0000-0003-4925-7600)
- Sebastian Regnery (ORCID: https://orcid.org/0000-0002-6820-884X)
- L. Wessel
- Philipp Schröter
- Harold Lau (ORCID: https://orcid.org/0000-0003-0947-933X)
- Gerhard Dyckhoff (ORCID: https://orcid.org/0000-0002-4316-4908)
- Jürgen Hoffmann
- Henrik Franke
- Thomas Held (ORCID: https://orcid.org/0000-0002-3913-4693)
- Lukas Bauer (ORCID: https://orcid.org/0009-0000-7711-934X)
- Karl Semmelmayer (ORCID: https://orcid.org/0000-0002-5187-1362)
- Julius Moratin (ORCID: https://orcid.org/0000-0002-0278-7228)
- Oliver Ristow (ORCID: https://orcid.org/0000-0002-3911-262X)
- Katharina Weusthof (ORCID: https://orcid.org/0000-0002-7307-484X)
- Florian Stritzke (ORCID: https://orcid.org/0000-0001-5099-3221)
- Jürgen Debus (ORCID: https://orcid.org/0000-0002-6411-4811)
- Anna Hofmann (ORCID: https://orcid.org/0000-0002-4480-6028)
- Katharina Dvornikovich
- Peter K. Plinkert
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Heidelberger Institut für Radioonkologie (DE)
- National Center for Tumor Diseases (DE)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s13014-025-02641-8
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitätsklinikum Heidelberg