Exploring the importance of bodyset for the psychedelic experience and beyond

Abstract Background Research has shown that psychedelics may have therapeutic potential in treating mental disorders like depression and anxiety. However, the mechanisms and actions underlying their effects are still not fully understood. Similarly, while the significance of mindset and setting in shaping psychedelic experiences and therapeutic outcomes is well established, information about the influence of the body is comparatively scarce. Aim This paper introduces the concept of bodyset, defined as the state of the body, including both the body and brain. We suggest it as a vital element in preparing for psychedelic experiences and beyond, broadening the traditional ‘set and setting’ framework. Methods Through an extensive literature review, we demonstrate the likely importance of the body in wellbeing, peak performance and peak experiences. Results Comprehensive multidisciplinary research, particularly focusing on various biomarkers, is needed to elucidate the potential role of bodyset in the psychedelic experience and therapy outcomes, and to guide future treatment approaches for mental health disorders. Conclusion Our exploration of the bodyset concept emphasizes the importance of considering not only psychological and environmental factors (mindset & setting), but also the physical state of the body in preparation for psychedelic experiences and psychedelic therapy. This holistic perspective may enhance our comprehension of their effects, therapeutic potential and inform the application of other treatment modalities, such as breathwork, in mental health care.