Xiao Yao San mitigates corticosterone stimulation-induced hippocampal neuronal damage by inhibiting GR phosphorylation and nuclear translocation via FKBP4 involvement
Xiao Yao San exhibited promising effects in ameliorating changes in corticosterone stimulation-induced neuroplasticity through the modulation of the GR signaling pathway. By inhibiting FKBP51-mediated GR phosphorylation and nuclear translocation, Xiao Yao San has potential as an alternative therapeutic strategy for corticosterone stimulation-related conditions. Further clinical investigations and mechanistic studies are warranted to validate its therapeutic efficacy and elucidate its mechanisms of action.
Authors
- Songjun Lin (ORCID: https://orcid.org/0000-0003-3954-9247)
- Hong Wan (ORCID: https://orcid.org/0000-0003-3794-5692)
- Ting Wang (ORCID: https://orcid.org/0000-0002-0241-0092)
- Wenjun Fu (ORCID: https://orcid.org/0000-0002-0545-2343)
- Xuedi Kang
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12906-025-04892-0
- Citations
- 1
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Sanming Project of Medicine in Shenzhen