Host Biomarkers and Antibiotic Tissue Penetration in Sepsis: Insights from Moxifloxacin
Biomarker tissue correlations suggest that the penetration of moxifloxacin into tissues is a complex process influenced by factors like inflammation, tissue integrity, liver function, protein levels, and renal function. Understanding these interactions might help optimize antibiotic dosing strategies.
Authors
- Markus Zeitlinger (ORCID: https://orcid.org/0000-0002-1873-3953)
- Maria Sanz-Codina (ORCID: https://orcid.org/0000-0002-1687-5296)
- Hartmuth Nowak (ORCID: https://orcid.org/0000-0002-6509-1463)
Institutions
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- European Journal of Drug Metabolism and Pharmacokinetics
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1007/s13318-025-00945-4
- Citations
- 3
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- European Commission
- Universität Wien
- Medizinische Universität Wien
- HORIZON EUROPE Marie Sklodowska-Curie Actions