Renal tubular epithelial cell-derived Exosomal miR-330-3p plays a key role in fibroblast activation and renal fibrosis by regulating CREBBP
The findings suggest that exosomes play an important role in promoting renal fibrosis by mediating the communication between renal tubular epithelial cells and fibroblasts. This role is associated with inhibition of CREBBP activity by exosomal miR-330-3p in fibroblasts. Thus, the miR-330-3p/CREBBP axis is a promising target for the treatment and management of renal fibrosis.
Authors
- Rong Dai (ORCID: https://orcid.org/0000-0001-7873-634X)
- Meng Cheng (ORCID: https://orcid.org/0000-0003-4137-903X)
- Chang G. Peng
- Hua Jin (ORCID: https://orcid.org/0000-0001-5478-4611)
- Yiping Wang
- Dong Wang (ORCID: https://orcid.org/0000-0002-4745-8073)
- Zhe Cao (ORCID: https://orcid.org/0000-0001-6993-9209)
- Lei Zhang (ORCID: https://orcid.org/0009-0005-9012-9952)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s13287-025-04338-x
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China