Longitudinal association of cumulative risk factors in early life, genetic risk, and healthy lifestyles during adulthood with the risk of type 2 diabetes
Early-life risk factors are associated with a higher risk of T2D in a dose-response manner, regardless of genetic risk or later-life healthy lifestyle. Therefore, identifying early-life modifiable risk factors is helpful to develop strategies of T2D prevention.
Authors
- Izzuddin M. Aris (ORCID: https://orcid.org/0000-0002-9239-7476)
- Honghao Yang
- Zhe Yang (ORCID: https://orcid.org/0000-0001-7246-0012)
- Borui Liu (ORCID: https://orcid.org/0000-0002-1398-3144)
- Zheng Lu (ORCID: https://orcid.org/0000-0002-0287-5826)
- Xiaoyan Zhang (ORCID: https://orcid.org/0009-0002-8339-2136)
- H. J. Yang (ORCID: https://orcid.org/0009-0004-8274-9863)
- Yilin Liu (ORCID: https://orcid.org/0000-0002-6661-6313)
- Xiaochuan Wang (ORCID: https://orcid.org/0000-0003-3768-324X)
- Yang Xia (ORCID: https://orcid.org/0000-0001-8783-1592)
- Hong Cui (ORCID: https://orcid.org/0000-0001-5734-825X)
- Jiajin Hu
Institutions
- Shenyang Medical College (CN)
- Harvard Pilgrim Health Care (US)
- China Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12916-025-04025-x
- Citations
- 3
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- China Association for Science and Technology
- National Natural Science Foundation of China
- Liaoning Revitalization Talents Program