<i>N</i>-Heterocyclic Carbene-Catalyzed [4 + 2] Annulation of Enolizable Thioesters for the Synthesis of 2-Pyrones
An <i>N</i>-heterocyclic carbene (NHC)-catalyzed [4 + 2] annulation enables the direct synthesis of 2-pyrones from α-chlorothioesters and β,γ-unsaturated α-keto esters or chalcones. The method utilizes NHC-activated α-chlorothioesters to generate key intermediates for 2-pyrone formation with high functional group tolerance. Moreover, the 2-pyrones were transformed into polysubstituted benzene and naphthalene derivatives, showcasing their synthetic value.
Authors
- Jinfeng Zhang (ORCID: https://orcid.org/0000-0001-9849-283X)
- Lixin Zhang (ORCID: https://orcid.org/0000-0003-0894-9520)
- Hui Jin (ORCID: https://orcid.org/0000-0002-7154-5628)
- Xu Cao (ORCID: https://orcid.org/0000-0002-7923-0188)
- Chen Zhu (ORCID: https://orcid.org/0009-0000-1150-1976)
Institutions
- Shenyang University of Chemical Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1021/acs.joc.5c00428
- Citations
- 1
- Primary Topic
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Natural Science Foundation of Liaoning Province
- Shenyang University of Chemical Technology