Silver-catalyzed direct decarboxylative C H functionalization of azauracils with aliphatic carboxylic acids

We propose a novel method for the C H alkylation of azauracils using aliphatic carboxylic acids as alkyl radical precursors, catalyzed by silver . This technique marks a substantial progress in organic synthesis, providing a flexible and effective route for azauracils modification. The method has been successfully applied to a diverse array of primary, secondary and tertiary carboxylic acids , highlighting its broad utility and reliability. The applicability of this method allows the preparation of a range of alkylated azauracil derivatives, which are potential intermediates for the creation of new pharmaceuticals, agrochemicals , and materials. We propose a novel method for the C H alkylation of azauracils using aliphatic carboxylic acids as alkyl radical precursors, catalyzed by silver. The applicability of this method allows the preparation of a range of alkylated azauracil derivatives in satisfactory yields via a radical process, which are potential intermediates for the creation of new pharmaceuticals, agrochemicals, and materials. • Azauracils are important synthetic targets because they have a broad spectrum of biological activities and serve as preeminent synthetic reagents in organic synthesis. • Silver-catalyzed direct decarboxylative C H functionalization of azauracils with aliphatic carboxylic acids to construct alkylated azauracil derivatives is firstly described. • The reaction is carried out under mild reaction conditions to give alkylated azauracils in moderate to good yields (34–88 %). • In addition, the late-stage modification of drug was performed.