Discovering the Hepatoprotective Properties of ARA290 in Acetaminophen-Induced Liver Toxicity
Introduction: Erythropoietin (EPO), known for its hematopoietic function, also has anti-inflammatory, antiapoptotic, antioxidant, and cytoprotective effects. ARA290, a peptide derived from EPO, selectively interacts with the innate repair receptor and exhibits similar properties. ARA290 offers tissue protection like EPO but without the hematopoietic side effects that limit EPO’s clinical use. In vitro, bioassays are important in evaluating new agents with hepatoprotective effects. This study aimed to assess the effect of ARA290 pretreatment on acetaminophen (APAP)-induced damage in HepG2 cells.
Authors
- Nasrin Ghassemi-Barghi (ORCID: https://orcid.org/0000-0002-0673-4262)
- Ramina Fazeli
- Maryam Fakhri
Institutions
- University of Tehran (IR)
- Jahrom University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Applied In Vitro Toxicology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1089/aivt.2024.0026
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.56