Long-chain sulfatide enrichment is an actionable metabolic vulnerability in intraductal papillary mucinous neoplasm (IPMN)-associated pancreatic cancers
Our work identifies enhanced sulfatide metabolism as an early metabolic alteration in cystic precancerous lesions of the pancreas that persists through invasive neoplasia and a potential actionable vulnerability in IPMN-derived PDAC.
Authors
- Yihui Chen (ORCID: https://orcid.org/0000-0002-3528-6104)
- Ehsan Irajizad (ORCID: https://orcid.org/0000-0001-7510-4849)
- C. Max Schmidt (ORCID: https://orcid.org/0000-0003-2447-2128)
- Ricardo A. León-Letelier (ORCID: https://orcid.org/0000-0001-7575-0453)
- Mark W. Hurd (ORCID: https://orcid.org/0000-0002-6102-4925)
- Rongzhang Dou (ORCID: https://orcid.org/0000-0002-2566-7843)
- Robert A. Wolff (ORCID: https://orcid.org/0000-0002-6614-1610)
- Hamid Khoshfekr Rudsari (ORCID: https://orcid.org/0000-0002-7856-0038)
- Fredrik I. Thege (ORCID: https://orcid.org/0000-0002-1822-4526)
- Michael P. Kim (ORCID: https://orcid.org/0000-0002-8269-854X)
- Samir Hanash (ORCID: https://orcid.org/0000-0002-4210-1593)
- Kimal Rajapakshe (ORCID: https://orcid.org/0000-0002-0472-858X)
- Hiroyuki Katayama (ORCID: https://orcid.org/0000-0003-3117-1390)
- Anirban Maitra (ORCID: https://orcid.org/0000-0001-7923-9978)
- Kim‐Anh Do (ORCID: https://orcid.org/0000-0001-8710-7131)
- Michele Yip-Schneider
- Yuki Makino (ORCID: https://orcid.org/0000-0002-2690-4548)
- Edwin J. Ostrin (ORCID: https://orcid.org/0000-0002-4538-6539)
- Marta Sans (ORCID: https://orcid.org/0000-0002-7756-5101)
- Johannes Francois Fahrmann (ORCID: https://orcid.org/0000-0001-5088-0198)
- Jimin Min (ORCID: https://orcid.org/0000-0002-2309-7875)
- Mingxin Zuo
- Jennifer B. Dennison (ORCID: https://orcid.org/0000-0003-3067-0972)
- Riccardo Ballarò (ORCID: https://orcid.org/0000-0001-5505-9024)
- Pedro Enrique Guerrero (ORCID: https://orcid.org/0000-0003-2612-9235)
- Jinming Zhang (ORCID: https://orcid.org/0000-0002-4078-9048)
- Ranran Wu
- Jody Vykoukal
Institutions
- Indiana University Health (US)
- The University of Texas MD Anderson Cancer Center (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Gut
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1136/gutjnl-2025-335220
- Citations
- 3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 3.14