M2 microglia-derived small extracellular vesicles modulate NSC fate after ischemic stroke via miR-25-3p/miR-93-5p-TGFBR/PTEN/FOXO3 axis
M2-sEVs increased NSC proliferation and neuronal differentiation, and protected against IS, at least partially, via delivering miR-25-3p and miR-93-5p to downregulate TGFBR, PTEN, and FOXO3 expression in NSC.
Authors
- Yuguo Xia
- Tao Xu (ORCID: https://orcid.org/0000-0002-5630-0382)
- Yan Yi
- Tiange Chen (ORCID: https://orcid.org/0000-0001-9332-2882)
- Ziyang Chen (ORCID: https://orcid.org/0000-0002-3357-5412)
- Xin Chen (ORCID: https://orcid.org/0000-0002-5189-5647)
- Qian Zhang (ORCID: https://orcid.org/0000-0002-1774-9726)
- Jinfang Liu (ORCID: https://orcid.org/0000-0001-6986-1173)
- Yuejie Ai
- Jianwei Chen (ORCID: https://orcid.org/0000-0002-0082-6959)
- Zhenfei Tang
- Ganzhi Liu
Institutions
- Central South University (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s12951-025-03390-2
- Citations
- 9
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hunan Province
- National Postdoctoral Program for Innovative Talents