JAK3-deficient mini-pigs exhibit impaired lymphoid organogenesis, intestinal structure, and leukocyte/cytokine production
These results suggest that JAK3 KO mini-pigs can be used as an effective model for the development of therapies for SCID patients, as well as for regenerative medicine applications such as the development of patient-specific artificial organs.
Authors
- Kyung Soo Kang (ORCID: https://orcid.org/0000-0002-5547-7215)
- Kangjin Jeong (ORCID: https://orcid.org/0000-0001-7552-4448)
- Sun‐Uk Kim (ORCID: https://orcid.org/0000-0002-5168-6976)
- Bo‐Woong Sim (ORCID: https://orcid.org/0000-0002-4492-1085)
- Kyung Seob Lim (ORCID: https://orcid.org/0000-0002-9117-887X)
- Yena Jung
- Hae-Jun Yang
- Chang-Gi Hur (ORCID: https://orcid.org/0000-0003-4526-3886)
- Jae‐Jin Cha
- Bong‐Seok Song (ORCID: https://orcid.org/0000-0002-0489-6719)
- Deog‐Bon Koo (ORCID: https://orcid.org/0000-0001-7825-9598)
- Yeung Bae Jin (ORCID: https://orcid.org/0000-0001-6783-7970)
- Sang‐Rae Lee (ORCID: https://orcid.org/0000-0001-8400-5973)
- Pil‐Soo Jeong (ORCID: https://orcid.org/0000-0002-8477-4358)
- Eun-Ha Hwang
- Hwal-Yong Lee
- Jung Joo Hong (ORCID: https://orcid.org/0000-0002-9795-6513)
- Yong Woo Jung (ORCID: https://orcid.org/0000-0002-5599-0553)
- Philyong Kang (ORCID: https://orcid.org/0000-0001-5927-7766)
- Sanghoon Lee (ORCID: https://orcid.org/0000-0002-1265-3821)
- Seung Hwan Lee (ORCID: https://orcid.org/0000-0003-0856-8023)
- Hanna Kim (ORCID: https://orcid.org/0000-0002-0934-4411)
- Jin‐Man Kim (ORCID: https://orcid.org/0000-0003-0905-9730)
- Young‐Ho Park (ORCID: https://orcid.org/0000-0001-5405-1231)
- Jong‐Hee Lee (ORCID: https://orcid.org/0000-0001-9938-1306)
- Seung-Chan Lee
- Seon‐A Choi
- Seung‐Min Ha
- Hee-Chang Son
- Young‐Kug Choo (ORCID: https://orcid.org/0000-0003-3065-485X)
Institutions
- Pyeongtaek University (KR)
- Gyeongsang National University (KR)
- Chungnam National University (KR)
- Korea University (KR)
- Shingu College (KR)
- National Institute of Animal Science (KR)
- Ajou University (KR)
- Chung-Ang University (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Wonkwang University (KR)
- Daegu University (KR)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.jare.2025.04.036
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00