Clinical impact of bronchoalveolar lavage fluid metagenomic next-generation sequencing in immunocompromised patients with severe community-acquired pneumonia in ICU: a multicenter retrospective study
This study indicates that ICU patients with SCAP, particularly those who are immunocompromised, are more likely to have polymicrobial infections. mNGS in BALF provides rapid and comprehensive pathogen profiling of pulmonary infections, thereby having a positive impact on both the diagnosis, treatment and prognosis of immunocompromised patients with SCAP.
Authors
- Bangchuan Hu (ORCID: https://orcid.org/0000-0001-6246-5258)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-1239-3441)
- Jiancheng Zhuge (ORCID: https://orcid.org/0009-0009-2191-5174)
- Junjie Zhao (ORCID: https://orcid.org/0000-0002-9827-6798)
- Honglong Fang (ORCID: https://orcid.org/0009-0000-9697-5213)
- Runxi Zhuge
- Yong Sun (ORCID: https://orcid.org/0000-0002-3648-5308)
- Zhidan Hua
- Lingmin Yuan (ORCID: https://orcid.org/0000-0002-2289-3175)
- Xiaojing Zhang (ORCID: https://orcid.org/0000-0002-0595-3500)
- Xingxing Wang (ORCID: https://orcid.org/0000-0003-4638-3441)
- Kai Guo (ORCID: https://orcid.org/0009-0002-5171-3812)
- Liyan Qiu (ORCID: https://orcid.org/0000-0002-9722-4806)
- Yesong Wang (ORCID: https://orcid.org/0000-0002-1482-9843)
- Canhu Qiu (ORCID: https://orcid.org/0009-0005-3995-966X)
- Jian Luo
- Youqin Yan
- Jing Tang (ORCID: https://orcid.org/0000-0002-0821-4623)
- Kaiyu Wang (ORCID: https://orcid.org/0009-0007-8805-1839)
- Weiwen Zhang
Institutions
- Zhejiang Chinese Medical University (CN)
- Shanghai Medical College of Fudan University (CN)
- Wenzhou Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Beijing Founder Electronics (China) (CN)
- Quzhou University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Infection
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1007/s15010-025-02520-0
- Citations
- 6
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 8.13