Pan-cancer analysis and validation show GTF2E2’s diagnostic, prognostic, and immunological roles in regulating ferroptosis in endometrial cancer
Our findings underscore GTF2E2's multifaceted roles in cancer biology, highlighting its potential as a diagnostic biomarker, prognostic indicator, and immunotherapeutic target across various malignancies. This investigation has the potential to contribute significantly to a deeper understanding of the substantial involvement of GTF2E2 in human malignancies, particularly UCEC.
Authors
- Fei Zhong (ORCID: https://orcid.org/0000-0002-6280-9644)
- Xuejin Qin
- Zhengchun Zhu
- Nie Zhang
- Min-Seong Kang (ORCID: https://orcid.org/0009-0008-6607-800X)
- Di Zhang (ORCID: https://orcid.org/0000-0002-2616-3874)
- Jingjing Liu (ORCID: https://orcid.org/0000-0002-5331-7015)
- Ke Han (ORCID: https://orcid.org/0000-0003-0279-4150)
Institutions
- Anhui Medical University (CN)
- National Health and Family Planning Commission (CN)
- Fuyang Second People's Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1371/journal.pone.0321983
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00