Clinical characteristics and therapeutic outcomes of obesity treated by endoscopic intragastric balloon placement

Objective: To describe clinical characteristics and evaluate treatment outcomes of obesity using endoscopic intragastric balloon placement. Subject and method: A prospective cross-sectional study was conducted on 86 obese patients who underwent Orbera and Spatz balloon placement from October 2010 to December 2023. Result: The study of 86 obese patients revealed a female predominance (68.6%) and a majority aged <30 years (53.5%), with a mean BMI of 36.0±4.5 kg/m². Following intragastric balloon placement, statistically significant reductions in weight and BMI were observed at all follow-up intervals (p<0.001), with mean weight decreasing from 95.1 kg to 77.3 kg at 6 months and %FWL reaching 47.6±6.1%. Both technical and clinical success rates were 100%. Significant improvements in blood pressure, glucose, and lipid profiles were documented at 6 months (p<0.01). Conclusion: The typical obese patient in this study was female, under 30 years old, with fatigue and anxiety as predominant symptoms. Endoscopic intragastric balloon placement effectively promoted weight loss, improved BMI, and ameliorated metabolic disorders, achieving all therapeutic objectives.