Treatment of hypothyroidism with the combination of levothyroxine and slow-release triiodothyronine: a randomized clinical trial
The novel combination of SRT3 + LT4 therapy resulted in a significant increase in serum T3 and the T3/fT4 ratio in hypothyroid patients compared to those receiving LT4 monotherapy. The rise in the T3/fT4 ratio was ≥ 21 % in two-thirds of patients; the lack of a significant increase in the T3/fT4 ratio in some patients during SRT3-LT4 combination therapy demands further investigation.
Authors
- Seyed Mohsen Foroutan (ORCID: https://orcid.org/0000-0003-2234-2434)
- Hengameh Abdi (ORCID: https://orcid.org/0000-0002-6850-0090)
- Seyed Jalil Masoumi (ORCID: https://orcid.org/0000-0001-6712-6802)
- Ladan Mehran (ORCID: https://orcid.org/0000-0001-8568-7419)
- Ali Siamak Habibi Moeini
- Fereidoun Azizi (ORCID: https://orcid.org/0000-0002-6470-2517)
- Amir Esmaeel Saghafinia
- Atieh Amouzegar (ORCID: https://orcid.org/0000-0003-1046-0003)
Institutions
- Research Institute for Endocrine Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Journal of Clinical & Translational Endocrinology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.jcte.2025.100395
- Citations
- 1
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Shahid Beheshti University of Medical Sciences