Human embryonic stem cell-derived immunity-and-matrix-regulatory cells promote endometrial repair and fertility restoration in IUA rats
Our study demonstrated that IMRCs inhibited TGF-β1-induced fibrosis in HESCs, suppressed the EMT process ex vivo, reduced the inflammatory response, and reversed endometrial damage and fibrosis in IUA rats. IMRCs exerted their effects through the paracrine pathway, with specific miRNAs in Exos downregulating the TGF-β/Smad signaling pathway to inhibit uterine endometrial fibrosis. IMRCs provide a new direction for the treatment of IUA.
Authors
- Jinyuan Huang (ORCID: https://orcid.org/0000-0002-3739-3114)
- Yuting Cao (ORCID: https://orcid.org/0000-0001-5896-0117)
- Xin Fan
- Yi Zhang (ORCID: https://orcid.org/0000-0002-8452-9694)
- Lin Li (ORCID: https://orcid.org/0000-0002-8014-8296)
- Jian Wu (ORCID: https://orcid.org/0000-0002-3394-1507)
- Yinmei Dai
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1186/s13287-025-04298-2
- Citations
- 7
- Primary Topic
- Gynecological conditions and treatments
- Type
- article
- Field-Weighted Citation Impact
- 14.40