<i>ap4b1</i> −/− zebrafish demonstrate morphological and motor abnormalities
This study characterizes an ap4b1-/- zebrafish model that recapitulates some phenotypes of SPG47, including motor deficits and morphological abnormalities. These findings support the utility of zebrafish for studying AP-4 deficiency and provide a platform for investigating the molecular mechanisms underlying SPG47.
Authors
- Hyo‐Min Kim (ORCID: https://orcid.org/0000-0002-2667-3719)
- Darius Ebrahimi‐Fakhari (ORCID: https://orcid.org/0000-0002-0026-4714)
- Angelica D’Amore (ORCID: https://orcid.org/0000-0003-4960-2689)
- Helena Rosengarten
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Human Molecular Genetics
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1093/hmg/ddaf056
- Citations
- 1
- Primary Topic
- Hereditary Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.91