MAGI1 attenuates osteoarthritis by regulating osteoclast fusion in subchondral bone through the RhoA-ROCK1 signaling pathway
This study reveals that the scaffold protein MAGI1 participates in osteoarthritis progression by regulating osteoclast fusion, providing novel theoretical foundations and potential therapeutic targets for osteoarthritis treatment.
Authors
- Fei Kang (ORCID: https://orcid.org/0000-0001-7820-7173)
- Shiwu Dong (ORCID: https://orcid.org/0000-0002-5032-4893)
- Jian‐Mei Li (ORCID: https://orcid.org/0000-0002-3294-3818)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-8449-6554)
- Xuan Yao (ORCID: https://orcid.org/0009-0003-2336-5045)
- Yuheng Li (ORCID: https://orcid.org/0000-0002-0648-4136)
- Wenhui Hu (ORCID: https://orcid.org/0000-0002-8886-7260)
Institutions
- Chongqing University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.jot.2025.04.007
- Citations
- 6
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing