Plasma TAR DNA-binding protein 43 (TDP-43) levels in a population-based cohort of older adults: The cardiovascular health study
Brain deposition of transactive response DNA-binding protein 43 (TDP-43) is a feature of neurodegenerative syndromes. We evaluated TDP-43 plasma concentrations in 1058 participants in the Cardiovascular Health Study (CHS), a population-based longitudinal cohort. The cohort was 38% male, 11% Black, had a mean age 75 years, and 261 people developed dementia over a mean of 5.5 years of follow up. Median TDP-43 levels were 211.0 pg/mL (IQR: 134.0-341.0 pg/mL). TDP-43 levels were not associated with cross-sectional or longitudinal change in cognitive scores, with plasma AD biomarkers, with brain MRI volumes, with incident dementia, or with demographic characteristics.
Authors
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Alison E. Fohner (ORCID: https://orcid.org/0000-0003-4231-3331)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- W. T. Longstreth
- Colleen M. Sitlani (ORCID: https://orcid.org/0000-0001-7656-7482)
- Russell P. Tracy (ORCID: https://orcid.org/0000-0002-0080-2420)
- Suman Jayadev (ORCID: https://orcid.org/0000-0003-3164-9665)
- Joshua C. Bis (ORCID: https://orcid.org/0000-0002-3409-1110)
- Oscar L. Lopez
- Bruce M. Psaty
Institutions
- University of Vermont (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Pittsburgh (US)
- University of Washington (US)
- Geriatric Research Education and Clinical Center (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1177/13872877251334820
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00