HMGB1 regulates the activation of dendritic cells and CD4+ T cell responses through the modulation of autophagy in bleomycin-induced pulmonary fibrosis
HMGB1 modulates DC autophagy, thereby affecting their activation and immune responses of CD4+ T cells in bleomycin-induced PF. Targeting HMGB1 and the autophagy pathway may provide new strategies for the treatment of PF.
Authors
- Xiuhua Liu (ORCID: https://orcid.org/0000-0001-6958-0478)
- Guangting Li (ORCID: https://orcid.org/0009-0006-6102-6812)
- Ligang Jie (ORCID: https://orcid.org/0000-0001-5017-6272)
- Hongyan Du (ORCID: https://orcid.org/0000-0002-6052-6421)
- Kaijiang Tang (ORCID: https://orcid.org/0000-0001-7199-5293)
- Yuping Zhang (ORCID: https://orcid.org/0009-0004-3833-7474)
- Ning Liu (ORCID: https://orcid.org/0000-0002-8517-0652)
- Xinghui Song (ORCID: https://orcid.org/0009-0002-5204-4315)
Institutions
- Southern Medical University (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2025-04-23
- DOI
- https://doi.org/10.1016/j.imbio.2025.152906
- Citations
- 2
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04